Ugdh — Udp Glucose 6 Dehydrogenase is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| UGDH | |
|---|---|
| UDP-Glucose 6-Dehydrogenase | |
| Gene Symbol | UGDH |
| Full Name | UDP-Glucose 6-Dehydrogenase |
| Chromosome | 4p15.1 |
| NCBI Gene ID | 54586 |
| Ensembl ID | ENSG00000108639 |
| OMIM | 603528 |
| UniProt ID | Q9Y2K2 |
| Associated Diseases | Parkinson's Disease, Alzheimer's Disease |
| Expression | Liver, Kidney, Brain, Lung, Heart |
UGDH (UDP-Glucose 6-Dehydrogenase) is an enzyme that catalyzes the oxidation of UDP-glucose to UDP-glucuronic acid. This enzyme is crucial for the biosynthesis of glycosaminoglycans, glucuronic acid metabolism, and cellular detoxification pathways.
UGDH catalyzes the NAD-dependent oxidation of UDP-glucose:
The study of Ugdh — Udp Glucose 6 Dehydrogenase has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.