Ubqln3 — Ubiquilin 3 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
:: infobox .infobox-gene
| Gene Symbol | UBQLN3 |
| Full Name | Ubiquilin 3 |
| Chromosomal Location | Xp11.23 |
| NCBI Gene ID | 50628 |
| OMIM | 301052 |
| Ensembl ID | ENSG00000166394 |
| UniProt | Q9H7D9 |
| Associated Diseases | Amyotrophic Lateral Sclerosis, Frontotemporal Dementia |
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UBQLN3 (Ubiquilin 3) is a member of the ubiquilin family of proteins involved in protein quality control. While less studied than UBQLN1 and UBQLN2, UBQLN3 is expressed in the brain and has been implicated in neurodegenerative diseases. It shares structural features with other ubiquilins, including an N-terminal ubiquitin-like (Ubl) domain and a C-terminal ubiquitin-associated (UBA) domain. UBQLN3 is primarily expressed in testis and brain tissue.
UBQLN3 participates in protein quality control mechanisms:
UBQLN3 has been linked to ALS through:
UBQLN3 shows tissue-specific expression:
The study of Ubqln3 — Ubiquilin 3 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.