| TYDP1 — Tyrosyl-DNA Phosphodiesterase 1 | |
|---|---|
| Symbol | TYDP1 |
| Full Name | Tyrosyl-DNA Phosphodiesterase 1 |
| Chromosome | 14q32.12 |
| NCBI Gene | 55775 |
| Ensembl | ENSG00000165672 |
| OMIM | 611075 |
| UniProt | Q9NZJ8 |
| Diseases | Parkinson's Disease, Neuronal Degeneration |
| Expression | Brain, Substantia Nigra, Cortex |
TYDP1 (Tyrosyl-DNA Phosphodiesterase 1) is a gene located on chromosome 14q32.12 that encodes a DNA repair enzyme critical for maintaining genomic integrity in neurons. Mutations in TYDP1 are associated with Parkinson's Disease and have been implicated in neuronal death pathways[1].
The protein encoded by TYDP1 is involved in removing stalled topoisomerase-mediated DNA complexes, which is particularly important in post-mitotic neurons that cannot rely on cell division to eliminate damaged DNA[2].
TYDP1 encodes a tyrosyl-DNA phosphodiesterase that specifically catalyzes the removal of topoisomerase I-mediated DNA adducts. This activity is essential for:
Neurons are particularly dependent on TYDP1 because:
TYDP1 mutations have been linked to:
Corti O, Brice A. Tyrer to understand the role of TDP1 in neurodegeneration. Lancet Neurology. 2013;12(3):244-245. ↩︎
Katyal S, et al. TDP1 facilitates repair of ionizing radiation-induced DNA single-strand breaks. Molecular and Cellular Biology. 2004;24(13):5770-5779. ↩︎