Txnrd1 — Thioredoxin Reductase 1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Official Symbol: TXNRD1 [1]
Official Full Name: Thioredoxin Reductase 1 [2]
Gene Type: Protein Coding [3]
Location: Chromosome 12q23.3 [4]
NCBI Gene ID: 7296 [5]
Ensembl ID: ENSG00000198431 [6]
UniProt ID: Q16881 [7]
Thioredoxin Reductase 1 (TXNRD1) is a selenoprotein that catalyzes the NADPH-dependent reduction of thioredoxin (TXN), maintaining it in a reduced, active state. As a key component of the thioredoxin system, TXNRD1 is essential for cellular redox homeostasis, antioxidant defense, and DNA synthesis. In the brain, TXNRD1 plays important roles in protecting neurons from oxidative stress and maintaining synaptic function.
The study of Txnrd1 — Thioredoxin Reductase 1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Nordberg J et al. TXNRD1 in brain (2001). 2001. ↩︎
Lovell MA et al. TXNRD1 in AD (2000). 2000. ↩︎
Bae SH et al. TXNRD1 and neurodegeneration (2013). 2013. ↩︎
Zhang J et al. TXNRD1 in PD (2018). 2018. ↩︎
Urig S et al. TXNRD1 as drug target (2006). 2006. ↩︎
Kahroba H et al. TXNRD1 in cancer therapy (2019). 2019. ↩︎
Liu Y et al. TXNRD1 and synaptic function (2021). 2021. ↩︎