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| Symbol | TRPV3 |
| Full Name | Transient Receptor Potential Cation Channel Subfamily V Member 3 |
| Chromosome | 17p13.2 |
| NCBI Gene | 7445 |
| OMIM | 607350 |
| Ensembl | ENSG00000167771 |
| UniProt | Q8NET8 |
| Associated Diseases | Skin function, pain, cognition |
TRPV3 is a gene encoding a transient receptor potential (TRP) channel that plays important roles in sensory transduction and has been implicated in neurodegenerative diseases.
The TRPV3 gene encodes a non-selective cation channel belonging to the TRP superfamily. These channels are activated by various stimuli including temperature, chemicals, and mechanical force, and contribute to cellular calcium signaling.
TRP channels are widely expressed in the nervous system and participate in sensory perception, neuroprotection, and disease processes. The TRPV3 channel has been studied in the context of oxidative stress, neuroinflammation, and neurodegenerative conditions including Alzheimer's and Parkinson's disease.
TRPV3 is a temperature-sensitive ion channel activated by warm temperatures (around 33-39°C). It is expressed in the skin, brain, and sensory neurons, and is involved in thermosensation and skin barrier function.
TRPV3 is a thermosensitive channel expressed in skin and brain. Important for thermal sensation and cognitive function.
Expressed in keratinocytes and brain.