TRIM3 is a brain-specific E3 ubiquitin ligase involved in neuronal development, postsynaptic density organization, and protein quality control. It localizes to the postsynaptic density and regulates synaptic protein turnover.
| Property | Value |
|---|---|
| Gene Symbol | TRIM3 |
| Gene Name | Tripartite Motif Containing 3 |
| Chromosomal Location | 19p13.3 |
| NCBI Gene ID | 10624 |
| OMIM | 605493 |
| UniProt | O75376 |
TRIM3 is a brain-specific E3 ubiquitin ligase involved in neuronal development, postsynaptic density organization, and protein quality control. It localizes to the postsynaptic density and regulates synaptic protein turnover.
The TRIM3 gene is associated with the following neurodegenerative and related diseases:
TRIM3 expression and its relevance to brain function is under active investigation.