TRIM20 (Pyrin) is an inflammasome component that regulates IL-1beta production and inflammatory responses. Mutations cause familial Mediterranean fever, and dysregulated inflammasome activity is implicated in various neurodegenerative conditions.
| Property | Value |
|---|---|
| Gene Symbol | TRIM20 |
| Gene Name | Tripartite Motif Containing 20 (Pyrin) |
| Chromosomal Location | 16p13.3 |
| NCBI Gene ID | 11008 |
| OMIM | 607112 |
| UniProt | Q15544 |
TRIM20 (Pyrin) is an inflammasome component that regulates IL-1beta production and inflammatory responses. Mutations cause familial Mediterranean fever, and dysregulated inflammasome activity is implicated in various neurodegenerative conditions.
The TRIM20 gene is associated with the following neurodegenerative and related diseases:
TRIM20 expression and its relevance to brain function is under active investigation.