Tmem57 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The TMEM57 gene (Transmembrane Protein 57) encodes a conserved multipass transmembrane protein primarily localized to the endoplasmic reticulum (ER). TMEM57 has been implicated in ER stress response, lipid metabolism, and more recently in Parkinson's disease pathogenesis through its genetic association with LRRK2-mediated pathways.
| Attribute | Value |
|---|---|
| Symbol | TMEM57 |
| Full Name | Transmembrane Protein 57 |
| Chromosomal Location | 4p15.32 |
| NCBI Gene ID | 84068 |
| Ensembl ID | ENSG00000155008 |
| UniProt | Q9Y2H5 |
TMEM57 is a 419-amino acid protein with:
The functions of TMEM57 are still being characterized:
TMEM57 is widely expressed with highest levels in:
In the brain, expression is found in:
The study of Tmem57 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.