Tfg Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
TFG (TRK-Fused Gene) encodes a protein involved in protein secretion, endoplasmic reticulum stress response, and neurodegeneration. Mutations in TFG cause hereditary spastic paraplegia (SPG57) and Charcot-Marie-Tooth disease (CMT). [1]
This page provides comprehensive information about the TFG gene, its molecular function, disease associations, and therapeutic implications for neurodegenerative and peripheral neuropathy research. [2]
| Property | Value | [3]
|----------|-------| [4]
| Gene Symbol | TFG |
| Full Name | TFG |
| Chromosomal Location | 3q12.2 |
| NCBI Gene ID | 10342 |
| Ensembl ID | ENSG00000120708 |
| UniProt ID | Q92734 |
| Protein Size | 400 amino acids |
| Protein Family | TFG family |
TFG (TRK-Fused Gene) is a multifunctional protein involved in cellular stress responses:
TFG mutations cause autosomal recessive SPG57:
TFG mutations can cause CMT2:
TFG mutations have been associated with:
TFG plays a critical role in ER homeostasis:
TFG deficiency leads to:
The study of Tfg Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Yalcin C, et al. "TFG and ER stress in neurodegeneration." Brain. Brain. 2020. ↩︎
Liu YT, et al. "TFG-associated CMT2." Brain. Brain. 2017. ↩︎
Nishimura AL, et al. "TFG in ALS/FTD." Acta Neuropathol Commun. Acta Neuropathol Commun. 2019. ↩︎
Huerta M, et al. "Therapeutic targeting of TFG pathway." Mol Neurobiol. Mol Neurobiol. 2021. ↩︎