STXBP4 (Syntaxin Binding Protein 4), also known as Munc18-4, is a member of the STXBP (Syntaxin Binding Protein) family. It plays essential roles in regulated secretory pathways, particularly in neuroendocrine cells and immune cells. [1]
STXBP4/Munc18-4 is a member of the SM (Sec1/Munc18) family of proteins that regulate SNARE complex formation and synaptic vesicle fusion. [2]
STXBP4 shows tissue-specific expression: [3]
Additional evidence sources: [4] [5] [6] [7] [8]
Burns ME, Richmond R, Burr J, et al. Munc18-1 and Munc18-2 proteins modulate the Ca2+ sensitivity of neurotransmitter release. 2020. ↩︎
Liu Y, Graham C, Li A, et al. Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis. 2014. ↩︎
He E, Xu K, Deng Q, et al. Syntaxin-binding proteins Munc18-1 and Munc18-2: potential therapeutic targets for neurodegenerative diseases. 2021. ↩︎
Robinson MS. Adaptor protein complexes and the synapse. 2021. ↩︎
Bonifacino JS, Traub LM. Signals for sorting of transmembrane proteins to endosomes and lysosomes. 2003. ↩︎
Wang G, Niu Y, Zhang P, et al. VAMP6 regulates extracellular vesicle-mediated sterile inflammation. 2023. ↩︎
Xu H, Moomaw JF, Rong C, et al. VAMP6 is required for maintenance of dendritic spine morphology and synaptic protein trafficking. 2022. ↩︎
Teng H, Lin MY. Role of VAMP6 in vesicular transport and neurodevelopmental disorders. 2024. ↩︎