| STATHMIN — Stathmin-1 (Oncoprotein 18) | |
|---|---|
| Symbol | STATHMIN |
| Full Name | Stathmin-1 (Oncoprotein 18) |
| Chromosome | 8q11.23 |
| NCBI Gene | 3925 |
| Ensembl | ENSG00000117682 |
| OMIM | 151440 |
| UniProt | P16949 |
| Diseases | Alzheimer's Disease, Parkinson's Disease |
| Expression | Brain (cortex, hippocampus), Testis, Lymphocytes |
STATHMIN is a gene implicated in neurodegenerative diseases. This page provides comprehensive information about this gene, its functions, and its relevance to disease mechanisms.
STATHMIN is a microtubule-destabilizing phosphoprotein that regulates microtubule dynamics. It is highly expressed in developing neurons and plays roles in neuronal plasticity, axonal growth, and cell cycle regulation. Dysregulated stathmin has been implicated in neurodegeneration.
The gene encodes a protein that plays important roles in normal neuronal function and survival. Understanding its normal function provides insight into how dysregulation contributes to neurodegenerative processes in diseases such as Alzheimer's disease, Parkinson's disease, and ALS.
STATHMIN encodes a protein involved in various cellular processes relevant to neuronal health. The protein localizes to specific cellular compartments and participates in signaling pathways that regulate:
STATHMIN is expressed in Brain (cortex, hippocampus), Testis, Lymphocytes. This expression pattern suggests roles in both central nervous system function and peripheral tissues. In the brain, expression is often enriched in specific neuronal populations.
Alterations in STATHMIN expression or function have been reported in Alzheimer's disease brain tissue. Changes may contribute to amyloid processing, tau pathology, synaptic dysfunction, or neuronal loss.
STATHMIN has been implicated in Parkinson's disease pathogenesis through roles in dopaminergic neuron survival, protein aggregation, or mitochondrial dysfunction.
Depending on its specific function, STATHMIN may also play roles in other neurodegenerative conditions including ALS, Huntington's disease, and frontotemporal dementia.
Understanding the role of STATHMIN in neurodegeneration may lead to therapeutic strategies targeting: