| SLC24A4 — Solute Carrier Family 24 Member 4 | |
|---|---|
| Symbol | SLC24A4 |
| Full Name | Solute Carrier Family 24 Member 4 |
| Chromosome | 14q32.12 |
| NCBI Gene | 123041 |
| Ensembl | ENSG00000151148 |
| UniProt | Q9NWA5 |
| Diseases | Alzheimer's Disease |
| Expression | Brain, Retina, Kidney, Placenta |
Slc24A4 Gene Solute Carrier Family 24 Member 4 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
SLC24A4 (Solute Carrier Family 24 Member 4), also known as NCKX4 (Na+/Ca2+/K+ exchanger 4), is a gene located on chromosome 14q32.12 that encodes a potassium-dependent sodium/calcium exchanger. SLC24A4 is expressed in various tissues including the brain and is associated with Alzheimer's disease risk through genome-wide association studies[1].
SLC24A4 is a potassium-dependent sodium/calcium exchanger that plays a critical role in cellular calcium regulation:
The NCKX family of exchangers operates through a transport mechanism that couples the movement of sodium ions down their electrochemical gradient to the extrusion of calcium ions:
SLC24A4 variants are associated with AD risk through genome-wide association studies (GWAS):
The study of Slc24A4 Gene Solute Carrier Family 24 Member 4 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.