| SLC18A1 — Vesicular Monoamine Transporter 1 | |
|---|---|
| Symbol | SLC18A1 |
| Full Name | Solute Carrier Family 18 Member 1 |
| Alias | VMAT1, VAT1 |
| Chromosome | 8p21.3 |
| NCBI Gene | 6570 |
| UniProt | P54219 |
| Diseases | Parkinson's Disease, Depression, Anxiety |
| Expression | Substantia Nigra, Locus Coeruleus, Adrenal Medulla |
Slc18A1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
SLC18A1 (Solute Carrier Family 18 Member 1), also known as VMAT1 (Vesicular Monoamine Transporter 1), is a gene located on chromosome 8p21.3 that encodes a vesicular transporter responsible for packaging monoamine neurotransmitters into synaptic vesicles[1]. The gene is catalogued as NCBI Gene ID 6570.
VMAT1 is a 525 amino acid protein that uses a proton gradient to transport dopamine, norepinephrine, epinephrine, serotonin, and histamine into synaptic vesicles for storage and subsequent release[2].
VMAT1 mediates the vesicular storage of monoamine neurotransmitters:
VMAT1 operates via an antiport mechanism:
VMAT1 is primarily expressed in:
VMAT1 dysfunction may contribute to PD pathogenesis:
SLC18A1 polymorphisms are linked to:
Targeting VMAT1 offers therapeutic opportunities:
VMAT1 contains:
VMAT1 activity is modulated by:
Common SLC18A1 polymorphisms:
The study of Slc18A1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.