The SFN gene (Stratifin, also known as 14-3-3 sigma) encodes a member of the 14-3-3 protein family. Unlike other 14-3-3 isoforms, SFN (14-3-3 sigma) is particularly notable for its role as a tumor suppressor and its involvement in cell cycle regulation, DNA damage response, and neuronal function. It is one of the few 14-3-3 isoforms that can form homodimers. [1]
| Attribute | Value | [2]
|-----------|-------| [3]
| Gene Symbol | SFN | [4]
| Full Name | Stratifin (14-3-3 sigma) | [5]
| Chromosomal Location | 1p36.22 |
| NCBI Gene ID | 6278 |
| Ensembl ID | ENSG00000175793 |
| UniProt ID | P31947 |
| OMIM | 605225 |
SFN encodes 14-3-3 sigma, which has unique functions in neurons:
| Disease | Association Type | Mechanism |
|---|---|---|
| Alzheimer's Disease | Modifier | 14-3-3 sigma interacts with tau pathology; CSF levels altered in AD |
| Parkinson's Disease | Potential Role | May affect alpha-synuclein aggregation and neuronal survival |
| Amyotrophic Lateral SALS | Potential Role | Involved in DNA damage response relevant to ALS pathogenesis |
| Brain Tumors | Tumor Suppressor | SFN is commonly lost in various cancers; role in glioblastoma |
SFN is expressed in various tissues with notable brain expression in:
Hermeking H. The 14-3-3 cancer connection. Nature Reviews Cancer. 2003. ↩︎
Lodygin D, Hermeking H. Epigenetic silencing of 14-3-3 sigma in cancer. Seminars in Cancer Biology. 2006. ↩︎
Chan TA, et al. 14-3-3 sigma is required to prevent mitotic catastrophe after DNA damage. Nature. 1999. ↩︎
Benzinger A, et al. [Cerebrospinal fluid 14-3-3 proteins as biomarkers for prion disease](https://doi.org/10.1016/S1474-4422(05). Lancet Neurology. 2005. ↩︎
Steinacker P, et al. Neuronal 14-3-3 protein in health and disease. Journal of Neural Transmission. 2011. ↩︎