SERPINA1 encodes alpha-1 antitrypsin, a serine protease inhibitor. While classically known for its role in protecting lung tissue from elastase, recent research suggests SERPINA1 variants may influence neurodegenerative processes through oxidative stress and inflammation pathways.
| Property | Value |
|---|---|
| Gene Symbol | SERPINA1 |
| Gene Name | Serpin Family A Member 1 (Alpha-1 Antitrypsin) |
| Chromosomal Location | 14q32.13 |
| NCBI Gene ID | 5265 |
| OMIM | 107400 |
| UniProt | P01009 |
SERPINA1 encodes alpha-1 antitrypsin, a serine protease inhibitor. While classically known for its role in protecting lung tissue from elastase, recent research suggests SERPINA1 variants may influence neurodegenerative processes through oxidative stress and inflammation pathways.
The SERPINA1 gene is associated with the following neurodegenerative and related diseases:
SERPINA1 expression and its relevance to brain function is under active investigation.