SEPTIN10 (Septin 10) is a member of the septin family of GTP-binding proteins that are essential for cytokinesis, cell polarity, and cellular organization. Septins form hetero-oligomeric complexes that function as scaffolds and barriers in various cellular processes. In neurons, septins play important roles in synaptic function, axonal transport, and have been implicated in neurodegenerative diseases[1].
| Property | Value |
|---|---|
| Gene Symbol | SEPTIN10 |
| Gene Name | Septin 10 |
| Chromosomal Location | 2q36.3 |
| NCBI Gene ID | 10244 |
| UniProt ID | Q9NSE2 |
| Ensembl ID | ENSG00000165799 |
| Gene Type | Protein Coding |
SEPTIN10 belongs to the septin family characterized by:
Septins assemble into filaments and rings, forming higher-order structures essential for their cellular functions[2].
SEPTIN10 is expressed in:
In neurons, septins are enriched in:
SEPTIN10 dysregulation is implicated in AD:
In PD, septins contribute to:
Septin alterations in ALS include:
| Disease | Evidence | Mechanism |
|---|---|---|
| Alzheimer's Disease | Moderate | Synaptic dysfunction |
| Parkinson's Disease | Moderate | α-Synuclein interaction |
| ALS | Moderate | Protein aggregation |
| Cancer | Confirmed | Cell division defects |
| Protein | Interaction | Function |
|---|---|---|
| SEPT2 | Complex formation | Filament assembly |
| SEPT6 | Complex formation | Filament assembly |
| SEPT7 | Complex formation | Filament assembly |
| Actin | Binding | Cytoskeleton |
| Microtubules | Binding | Transport |
Septins represent potential therapeutic targets:
Mostowy S et al. Septins: the fourth component of the cytoskeleton. Nature Reviews Molecular Cell Biology. 2011. ↩︎
Kinoshita M. The septin family and its relationship to the nervous system. Journal of Chemical Neuroanatomy. 2003. ↩︎
Tòth K et al. Septins in neurodegenerative diseases. Frontiers in Cellular Neuroscience. 2019. ↩︎