Sema3F Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Semaphorin 3F | |
|---|---|
| Gene Symbol | SEMA3F |
| Full Name | Semaphorin 3F |
| Chromosome | 3p21.31 |
| NCBI Gene ID | 10507 |
| OMIM | 601874 |
| Ensembl ID | ENSG00000105618 |
| UniProt ID | Q13275 |
| Associated Diseases | Cancer, Tuberous Sclerosis |
SEMA3F is a gene/protein encoding a key neuronal protein involved in synaptic function, signal transduction, and cellular homeostasis. Dysfunction of SEMA3F is associated with neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and related disorders.
SEMA3F encodes semaphorin 3F, a secreted axon guidance molecule that signals through neuropilin-2 and plexin receptors. SEMA3F functions as a chemorepellent for developing axons and regulates blood vessel growth. It plays important roles in neural development and tissue patterning.
Expressed in various tissues, with high expression in the nervous system.
| Disease | Variants | Inheritance | Mechanism |
|---|---|---|---|
| Cancer | Various | Somatic | Impaired tumor suppression |
| Tuberous Sclerosis | Risk variants | Susceptibility | mTOR dysregulation |
The study of Sema3F Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.