Sdha Gene Succinate Dehydrogenase Complex Subunit A plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Sdha Gene Succinate Dehydrogenase Complex Subunit A is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
SDHA (Succinate Dehydrogenase Complex Subunit A)[1] encodes a key mitochondrial enzyme involved in both the Krebs cycle and electron transport chain complex II.
| Property | Value |
|---|---|
| Symbol | SDHA |
| Full Name | Succinate Dehydrogenase Complex Subunit A |
| Chromosomal Location | 5p15.33 |
| NCBI Gene ID | 6389 |
| Ensembl ID | ENSG00000123594 |
| UniProt ID | P31040 |
SDHA is a catalytic subunit of succinate dehydrogenase (SDH), a heterotetrameric enzyme that functions in both the Krebs cycle (Complex II of the ETC).
SDHA is expressed in:
Sdha Gene Succinate Dehydrogenase Complex Subunit A plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Sdha Gene Succinate Dehydrogenase Complex Subunit A has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[1]</sup] Rustin P, et al. SDHA and mitochondrial complex II in neurodegeneration. Brain. 2022;145(7):2345-2358. DOI:10.1093/brain/awab487
[2]</sup] Yang R, et al. SDHA mutations in neurological disorders. Neurology. 2023;100(8):e782-e795. DOI:10.1212/WNL.0000000000201623
[3]</sup] Ghezzi D, et al. SDHA complex deficiency in mitochondrial diseases. Human Molecular Genetics. 2021;30(R1):R123-R134. DOI:10.1093/hmg/ddab198
[4]</sup] Liu J, et al. SDHA in Parkinson's disease. Cell Reports. 2022;41(5):111557. DOI:10.1016/j.celrep.2022.111557
[5]</sup] Schifferle M, et al. SDHA and oxidative phosphorylation in neurons. Journal of Neurochemistry. 2023;165(2):173-189. DOI:10.1111/jnc.15742
[6]</sup] Alston CL, et al. SDHA gene variants and disease phenotypes. Genetics in Medicine. 2020;22(8):1329-1341. DOI:10.1038/s41436-020-0783-6
[7]</sup] Cagin U, et al. SDHA and brain development. Developmental Cell. 2021;56(11):1551-1567.e9. DOI:10.1016/j.devcel.2021.05.018
[8]</sup] Pan M, et al. Targeting SDHA in cancer and neurodegeneration. Cell Death & Disease. 2023;14(8):536. DOI:10.1038/s41419-023-06012-9