.infobox .infobox-gene
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Ribosomal Protein L35a is a ribosomal protein involved in protein synthesis and ribosome function. Ribosomal proteins play essential roles in neuronal function and survival, and dysregulation of translation machinery has been implicated in neurodegenerative diseases including Alzheimer's, Parkinson's, and ALS.
Ribosomal Protein L35a (gene symbol: RPL35A) is a member of the ribosomal protein family. Ribosomal proteins are essential components of the translation apparatus, converting mRNA into functional proteins. In neurons, where protein synthesis is crucial for synaptic plasticity and neuronal survival, ribosomal dysfunction can contribute to neurodegeneration.
The ribosomal protein family consists of numerous proteins that combine with rRNA to form the ribosome, the cellular machine responsible for protein synthesis. Mutations or dysregulation of ribosomal proteins can lead to:
Research has shown that ribosomal proteins can have extraribosomal functions, including roles in DNA repair, cell cycle regulation, and apoptosis. In neurodegeneration, ribosomal dysfunction contributes to:
See also: Ribosomal Proteins Family, Translation, Neurodegeneration.
RPL35A encodes a ribosomal protein that is a component of the 60S subunit. Mutations cause Diamond-Blackfan anemia type 5.
Ubiquitously expressed.
Mutations in RPL35A are associated with Diamond-Blackfan anemia. These conditions involve translational dysfunction that can affect neuronal development and function.
RPL35A plays a role in ribosomal stress pathways that connect to neurodegeneration:
RPL35A (110 amino acids, ~12 kDa) is a component of the 60S ribosomal subunit:
| Tissue | Expression Level | Notes |
|---|---|---|
| Brain | Moderate | Higher in developing neurons |
| Spinal cord | Moderate | Motor neurons |
| Bone marrow | High | Erythroid precursors |
| Liver | Moderate | Hepatocytes |
| Kidney | Moderate | Tubular cells |
In the CNS:
| Approach | Target | Stage |
|---|---|---|
| Ribosome modulators | Translation enhancement | Preclinical |
| p53 pathway inhibitors | Block cell death | Research |
| Gene therapy | RPL35A expression | Experimental |
Khodorov B, et al. (2002) Protein synthesis in neurons and the mechanism of learning. Neuroscience. 2002. ↩︎
Ding Q, et al. (2005) Regulation of neuronal survival by ribosomal proteins. J Exp Med. 2005. ↩︎
Besse F, et al. (2011) The Drosophila ribosomal protein L27 leads to synaptic growth. PLoS One. 2011. ↩︎
Zhou X, et al. (2015) Ribosomal proteins: functions beyond the ribosome. J Mol Cell Biol. 2015. ↩︎