| Symbol |
RNF14 |
| Full Name |
Ring Finger Protein 14 (ARA54) |
| Chromosome |
5q23.3 |
| NCBI Gene |
9744 |
| Ensembl |
ENSG00000082630 |
| OMIM |
605423 |
| UniProt |
Q9Y2X9 |
| Diseases |
[Prostate Cancer](/diseases/prostate-cancer), [Parkinson's Disease](/diseases/parkinsons-disease) |
| Expression |
Ubiquitously expressed; high expression in brain, testis, prostate |
RNF14 (Ring Finger Protein 14), also known as ARA54, is a gene located on chromosome 5q23.3 that encodes a RING finger E3 ubiquitin ligase. RNF14 was originally identified as an androgen receptor-associated protein and is involved in steroid hormone signaling, protein degradation, and various cellular processes. The gene has been implicated in cancer and neurodegenerative diseases [1][2].
The RNF14 gene spans approximately 35 kb and consists of 12 exons. The gene encodes a 511-amino acid protein containing multiple domains.
- Chromosome: 5q23.3
- Location: chr5: 132037147-132073096
- Strand: Minus strand
- Exons: 12
¶ Protein Structure and Function
¶ Domain Architecture
RNF14 contains:
- RING finger domain: C3H2C3-type RING finger for E3 ubiquitin ligase activity
- N-terminal region: Multiple zinc finger motifs
- C-terminal region: Dimerization and regulatory domains
¶ Androgen Receptor Signaling
- AR co-activator: Enhances androgen receptor transcriptional activity
- Nuclear translocation: Facilitates AR nuclear import
- Protein stability: Regulates AR protein levels via ubiquitination
- E3 ubiquitin ligase: Catalyzes protein ubiquitination
- Substrate specificity: Targets various cellular proteins
- Protein quality control: Degrades misfolded proteins
RNF14 is overexpressed in prostate cancer:
- Oncogenic role: Promotes cancer cell proliferation
- AR signaling: Enhances androgen-dependent growth
- Therapeutic target: Potential for targeted therapy
RNF14 has been implicated in PD:
- Dopaminergic neuron function: Essential for neuronal survival
- Protein aggregation: May affect alpha-synuclein clearance
- Mitochondrial function: Linked to mitochondrial quality control
RNF14 is ubiquitously expressed with highest levels in:
- Brain (especially basal ganglia)
- Testis
- Prostate
- Ovary
- Nuclear
- Cytoplasmic
- Associates with various organelles
- Targeting RNF14: Developing inhibitors to block RNF14-AR interaction
- Combination therapy: RNF14 inhibition with anti-androgen therapy
- Enhancing RNF14 function to protect dopaminergic neurons
- Gene therapy approaches