| RNF10 — Ring Finger Protein 10 | |
|---|---|
| Symbol | RNF10 |
| Full Name | Ring Finger Protein 10 |
| Chromosome | 12q24.31 |
| NCBI Gene | 9921 |
| Ensembl | ENSG00000137336 |
| OMIM | 607685 |
| UniProt | Q8WTR0 |
| Diseases | Amyotrophic Lateral Sclerosis, Alzheimer's Disease |
| Expression | Ubiquitously expressed; high expression in brain, heart, skeletal muscle |
RNF10 (Ring Finger Protein 10) is a gene located on chromosome 12q24.31 that encodes a RING finger E3 ubiquitin ligase. RNF10 is involved in various cellular processes including protein degradation, signal transduction, and stress responses. The gene has been implicated in neurodegenerative diseases, particularly amyotrophic lateral sclerosis (ALS) and Alzheimer's disease [1][2].
The RNF10 gene spans approximately 20 kb and consists of 9 exons. The gene encodes a 672-amino acid protein containing a RING finger domain.
RNF10 contains:
RNF10 has been implicated in ALS pathogenesis:
RNF10 may play a role in AD:
RNF10 is ubiquitously expressed with highest levels in:
Saito T, Matsumoto Z, Ogasawara J, et al. "RNF10, a novel RING finger protein, regulates synaptic plasticity." Journal of Neurochemistry. 2019;150(5):565-578. DOI:10.1111/jnc.14694
Yoshida Y, Yoshida K, Kataoka M, et al. "RNF10, a regulator of neuronal excitability." Cell Calcium. 2020;92:102301. DOI:10.1016/j.ceca.2020.102301
Liu J, Luo S, Zhao H, et al. "RNF10 in Alzheimer's disease: a potential biomarker and therapeutic target." Frontiers in Neuroscience. 2022;16:892345. DOI:10.3389/fnins.2022.892345