Rest Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
--- [1]
title: REST Gene [2]
description: Gene information for RE1-Silencing Transcription Factor and its role in neurodegenerative diseases [3]
| REST Gene | |
|---|---|
| Full Name | RE1-Silencing Transcription Factor |
| Chromosome | 4q12 |
| NCBI Gene ID | 5978 |
| OMIM | 600571 |
| Ensembl ID | ENSG00000100647 |
| UniProt ID | Q9Y2W1 |
| Encoded Protein | [REST](/proteins/rest) |
| Associated Diseases | Huntington's disease, Alzheimer's disease, Parkinson's disease, various cancers |
The REST gene (RE1-Silencing Transcription Factor) encodes a zinc-finger transcriptional repressor that regulates neuronal gene expression during development and in response to stress. REST acts as a master regulator of neuronal identity and protects neurons from oxidative stress and toxic insults. REST dysfunction is implicated in Alzheimer's disease, Huntington's disease, and aging-related neurodegeneration.
REST (also known as NRSF) is a zinc-finger transcription factor that represses neuronal gene expression in non-neuronal cells and regulates synaptic plasticity in neurons. It binds to RE1silencing elements (RSE) in target genes.
High expression in neural progenitor cells and non-neuronal tissues. In mature neurons, REST levels decrease to allow neuronal gene expression. REST is re-induced in some neurodegenerative conditions.
REST dysfunction is implicated in Huntington's disease, where mutant huntingtin sequesters REST in the cytoplasm, leading to dysregulation of REST target genes. REST may have both protective and pathological roles in neurodegeneration.
REST (RE1-Silencing Transcription factor), also known as NRSF (Neuron-Restrictive Silencer Factor), is a zinc-finger transcription factor that represses neuronal genes in non-neuronal cells and regulates synaptic plasticity in neurons. REST functions by binding to RE1 sites (TCAGCACCGANNGAG) in target gene promoters.
Key REST mechanisms include:
REST-targeted approaches for neurodegeneration:
Active research areas:
The study of Rest Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
REST (RE1-Silencing Transcription factor), also known as NRSF (Neuron-Restrictive Silencer Factor), is a zinc-finger transcription factor that represses neuronal genes in non-neuronal cells and regulates synaptic plasticity in neurons. REST functions by binding to RE1 sites (TCAGCACCGANNGAG) in target gene promoters.
Key REST mechanisms include:
REST-targeted approaches for neurodegeneration:
Active research areas: