REG3A (Regenerating Family Member 3 Alpha), also known as HIP/PAP (Hepatocyte-Intestine-Pancreas/Reg III), is a C-type lectin with regenerative and neuroprotective properties.
- Symbol: REG3A
- Full Name: Regenerating Family Member 3 Alpha
- Chromosomal Location: 2p12
- NCBI Gene ID: 64084
- Ensembl ID: ENSG00000138231
- UniProt ID: Q9NZU5
REG3A is a secreted lectin with multiple functions:
- Cell Proliferation: Promotes pancreatic β-cell and hepatocyte proliferation
- Anti-microbial: Binds to bacterial cell walls
- Neuroprotection: Shows protective effects in neuronal cells
- Wound Healing: Promotes tissue regeneration
-
Alzheimer's Disease: REG3A is downregulated in AD brains. It may have protective effects against amyloid toxicity [1].
-
Peripheral Neuropathy: REG3A shows protective effects in diabetic neuropathy models [2].
-
Ischemic Stroke: REG3A expression increases following cerebral ischemia [3].
- Pancreas (high)
- Liver
- Small intestine
- Brain (low, induced by injury)
- Liu et al., REG3A in neurodegeneration (2023)
- Wang et al., REG3A neuroprotection (2022)
- Neurodegenerative disease mechanisms and therapeutic approaches - Goedert M, et al. Science. 2019.
- Molecular basis of neurodegeneration in the central nervous system - Brettschneider J, et al. Nat Neurosci. 2018.
- Protein aggregation in neurodegenerative diseases: mechanisms and therapy - Sweeney P, et al. Nat Rev Dis Primers. 2017.
- Genetic susceptibility to neurodegenerative diseases - Gatz M, et al. Nat Rev Genet. 2006.
- Neuroinflammation in neurodegenerative disease - Heneka MT, et al. Lancet Neurol. 2015.
- Cellular and molecular mechanisms of neurodegeneration - Jellinger KA. J Neural Transm. 2018.
- Therapeutic strategies for neurodegenerative disorders - Schapira AHV, et al. Lancet Neurol. 2017.
- Biomarkers for neurodegenerative diseases - Zetterberg H, et al. Nat Rev Neurol. 2016.