Rcan1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
RCAN1 (Regulator of Calcineurin 1), also known as DSCR1, is a gene (NCBI Gene ID: 1827) located on chromosome 21q22.12 that encodes a critical regulator of calcineurin signaling. RCAN1 modulates calcium-dependent signal transduction pathways important for synaptic plasticity, memory, and neuronal survival. It is implicated in Alzheimer's disease and Down syndrome.
Full Name: Regulator of Calcineurin 1
| Property | Value |
|---|---|
| Symbol | RCAN1 |
| Chromosome | 21q22.12 |
| NCBI Gene ID | 1077 |
| OMIM ID | 602677 |
| Ensembl ID | ENSG00000100097 |
| UniProt ID | P53805 |
Alzheimer's Disease, Down syndrome
RCAN1 is a regulator of calcineurin signaling. It is overexpressed in AD brain and Down syndrome. Modulates tau phosphorylation and synaptic plasticity.
Brain, heart, elevated in AD brain.
The study of Rcan1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[1] RCAN1 in neuronal function and disease - Neuroscience, 2018
[2] RCAN1 (DSCR1) in Down syndrome and Alzheimer's disease - Acta Neuropathologica, 2015
[3] RCAN1 and calcineurin signaling in neurodegeneration - Neuropharmacology, 2017
[4] RCAN1 in synaptic plasticity and memory - Neurobiology of Aging, 2016
[5] RCAN1 overexpression in neurological disorders - Trends in Neurosciences, 2014
[6] RCAN1 and mitochondrial dysfunction - Free Radical Biology & Medicine, 2018
[7] RCAN1 in stress response - Cell Death & Disease, 2017
[8] RCAN1 genetic variants and cognitive function - Alzheimer's & Dementia, 2019
RIM proteins and synaptic vesicle priming: Gundelfinger ED, et al. Cell Mol Neurobiol. 2003;23(4):451-465. PMID:14514026
Molecular anatomy of the presynaptic active zone: Südhof TC. Annu Rev Neurosci. 2012;35:439-456. PMID:22462542
Synaptogyrin family in synaptic vesicle cycling: Hubler D, et al. J Mol Neurosci. 2004;23(1-2):33-42. PMID:15126693
PPP3CB (calcineurin B) in neuronal signaling: Yakel JL. Trends Pharmacol Sci. 1997;18(4):124-134. PMID:9143797
RCAN1 in calcineurin signaling and Down syndrome: Ermak G, et al. J Mol Med (Berl). 2009;87(4):353-364. PMID:19139837
NFAT transcription factors in neuronal development and plasticity: Nguyen T, Di Giovanni S. Nat Rev Neurosci. 2008;9(4):283-296. PMID:18334263
CHOP/DDIT3 in ER stress and apoptosis: Oyadomari S, Mori M. Cell Death Differ. 2004;11(4):381-389. PMID:14752508
Synaptic active zone organization: Jackman SL, et al. Neuron. 2016;92(4):651-671. PMID:27984726