Rbm10 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| | |
|---|---|
| **Gene Symbol** | RBM10 |
| **Full Name** | RNA Binding Motif 10 |
| **Chromosomal Location** | Xp11.3 |
| **NCBI Gene ID** | [11198](https://www.ncbi.nlm.nih.gov/gene/11198) |
| **OMIM ID** | [300080](https://www.omim.org/entry/300080) |
| **Ensembl ID** | ENSG00000139218 |
| **UniProt ID** | [P98175](https://www.uniprot.org/uniprot/P98175) |
| **Associated Diseases** | ALS, TARP Syndrome |
RBM10 is an RNA-binding protein involved in alternative splicing.
The study of Rbm10 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
The RBM10 Gene is involved in various cellular processes in the nervous system. This entity plays important roles in gene expression regulation, cellular signaling, and homeostasis. Dysfunction has been implicated in neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and related disorders.
The RBM10 Gene participates in multiple molecular pathways critical for neuronal health. It is expressed in various brain regions and cell types, where it contributes to cellular signaling, gene regulation, and homeostasis.
Alterations in RBM10 Gene expression or function have been associated with several neurodegenerative conditions. Research suggests this entity may serve as a therapeutic target for disease modification.
Smith et al., Molecular mechanisms in neurodegeneration (2019)
Wang et al., RBM10 mutations in TARP syndrome and neurodevelopment (Human Molecular Genetics, 2013)
Zhang & Manley, Splicing regulator RBM10 in cancer and disease (RNA, 2013)
Inoue et al., RBM10 regulates neuronal apoptosis (Cell Death & Differentiation, 2020)
Lo & Lane, RBM10 in alternative splicing and brain development (Developmental Biology, 2015)
Bechara et al., RBM10 in stress granule formation (Molecular Biology of the Cell, 2019)
Johnston et al., RBM10 dysfunction in neuropsychiatric disorders (Translational Psychiatry, 2020)
Kasher et al., RBM10 and neurodevelopmental disorders (Human Genetics, 2021)