| RAPTOR | |
|---|---|
| Full Name | Regulatory Associated Protein of mTORC1 |
| Chromosomal Location | 17q1.32 |
| NCBI Gene ID | [2004](https://www.ncbi.nlm.nih.gov/gene/2004) |
| OMIM | [607333](https://www.omim.org/entry/607333) |
| Ensembl ID | ENSG00000141551 |
| UniProt | [Q8N122](https://www.uniprot.org/uniprot/Q8N122) |
| Associated Diseases | Huntington's Disease, Alzheimer's Disease, Parkinson's Disease, Amyotrophic Lateral Sclerosis |
RICTOR is a human gene whose product rAPTOR (Regulatory-Associated Protein of mTOR) is an essential component of mTOR Complex 1 (mTORC1), serving as a scaffolding protein that recruits substrates to the mTOR kinase. RAPTOR directly binds to mTOR through its HEAT repeat domain and interacts with 4E-BP1 and S6K1 to facilitate their phosphorylation. Variants in RICTOR have been implicated in Neurodegenerative Diseases, Other Conditions. This page covers the gene's normal function, disease associations, expression patterns, and key research findings relevant to neurodegeneration.
RAPTOR (Regulatory-Associated Protein of mTOR) is an essential component of mTOR Complex 1 (mTORC1), serving as a scaffolding protein that recruits substrates to the mTOR kinase. RAPTOR directly binds to mTOR through its HEAT repeat domain and interacts with 4E-BP1 and S6K1 to facilitate their phosphorylation.
Key functions include:
RAPTOR is essential for embryonic development and tissue-specific functions including neuronal survival, synaptic plasticity, and oligodendrocyte myelination.
Huntington's Disease:
Alzheimer's Disease:
Parkinson's Disease:
Amyotrophic Lateral Sclerosis:
RAPTOR is widely expressed in the nervous system:
Expression is developmentally regulated, with higher levels during synaptogenesis and myelination.