Rapgef1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| RAPGEF1 | |
|---|---|
| Gene Symbol | RAPGEF1 |
| Full Name | Rap Guanine Nucleotide Exchange Factor 1 |
| Chromosome | 9q34.13 |
| NCBI Gene ID | 2889 |
| OMIM | 600996 |
| Ensembl ID | ENSG00000107281 |
| UniProt ID | Q9Y238 |
| Associated Diseases | Cancer, Neurodevelopmental Disorders |
This page provides comprehensive information about the subject's role in neurodegenerative diseases. The subject participates in various molecular pathways and cellular processes relevant to Alzheimer's disease, Parkinson's disease, and related conditions.
RAPGEF1 (also known as C3G) is a Rap1-specific guanine nucleotide exchange factor that activates Rap1 and R-Ras. It plays critical roles in:
C3G is essential for neuronal development and synaptic plasticity.
RAPGEF1 is expressed in:
| Disease | Association | Mechanism |
|---|---|---|
| Cancer | Often overexpressed | Enhanced cell adhesion and migration |
| Neurodevelopmental Disorders | Risk factor | Impaired neuronal development |
The study of Rapgef1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.