RAMP2 (Receptor Activity Modifying Protein 2) is a single-pass membrane protein that forms functional receptors with CALCRL for adrenomedullin (AM) and CGRP.
RAMP2 forms different receptor complexes:
Stroke: Adrenomedullin has protective effects in cerebral ischemia [1].
Alzheimer's Disease: AM signaling may be neuroprotective [2].
Cardiovascular Diseases: Dysregulated in hypertension and heart failure [3].