Rab11A Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Symbol | RAB11A |
|---|---|
| Full Name | RAB11A, member RAS oncogene family |
| Chromosome | 15q21.3 |
| NCBI Gene ID | 8766 |
| OMIM | 609758 |
| Ensembl ID | ENSG00000103740 |
| UniProt ID | P62491 |
This section provides a comprehensive overview of the gene/protein and its role in the nervous system and neurodegenerative diseases.
RAB11A encodes a small GTPase involved in regulated exocytosis and endocytic recycling. It plays a critical role in synaptic vesicle recycling, neurotransmitter release, and autophagosome maturation.
RAB11A dysfunction has been linked to Parkinson's disease and Alzheimer's disease. It is involved in the trafficking of alpha-synuclein and amyloid precursor protein. RAB11-mediated recycling is essential for dopamine receptor signaling.
RAB11A is ubiquitously expressed with high expression in the brain, particularly in the hippocampus, cortex, and basal ganglia. It is enriched in synaptic terminals.
The study of Rab11A Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.