Bbc3 — Bcl2 Binding Component 3 (Puma) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
This page provides comprehensive information about this gene. See the content below for detailed information.
PUMA (BBC3) is a pro-apoptotic BH3-only protein of the BCL-2 family. It is a critical mediator of p53-dependent and p53-independent apoptosis in neurodegeneration.
The BBC3 gene encodes PUMA (p53 upregulated modulator of apoptosis), a BH3-only protein of the BCL-2 family. PUMA is a potent inducer of apoptosis that functions by inhibiting anti-apoptotic BCL-2 proteins and activating pro-apoptotic BAX/BAK. It is a key mediator of both p53-dependent and p53-independent apoptotic pathways.
Alzheimer's Disease, Parkinson's Disease, Cancer — PUMA is upregulated in neurodegenerative diseases and mediates neuronal cell death in response to various insults. It is considered a promising therapeutic target for neuroprotection.
BBC3 is expressed in brain and tissues with high proliferation rates. Its expression is induced by p53, DNA damage, oxidative stress, and other apoptotic stimuli.
The study of Bbc3 — Bcl2 Binding Component 3 (Puma) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Yu J, et al. "PUMA is a novel downstream target of the p53 tumor suppressor." Cell. 2000;103(5):849-856. PMID:11136978
- Han J, et al. "Expression of BBC3/PUMA in normal human tissues and in Alzheimer's disease." Acta Neuropathol. 2007;113(4):451-458. PMID:17265049
- Villunger A, et al. "p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and bmf." Science. 2003;299(5603):621-624. PMID:12563007
- You H, et al. "PUMA and p53 are required for neuronal death induced by familial ALS-linked mutant SOD1." J Neurochem. 2006;97(2):363-371. PMID:16606350
- Kanck C, et al. "PUMA-mediated neuronal apoptosis in neurodegenerative diseases." Front Cell Neurosci. 2019;13:551. PMID:31866837
- Reimertz C, et al. "RNA expression of p53 target genes in neurons during endoplasmic reticulum stress." J Neurochem. 2003;87(3):581-591. PMID:14550552
- Karch J, et al. "Puma and bmf are required for synaptic activity-induced neuronal death." Cell Death Differ. 2014;21(8):1312-1323. PMID:24769731
- Wan YY, et al. "From the cover: PUMA is critical for neuronal vulnerability to neurodegeneration." J Neurosci. 2009;29(29):9080-9087. PMID:19605644
- Yu J, Zhang L, Hwang PM, et al. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell. 2001;7(3):673-682. DOI
- Nakano K, Vousden KH. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell. 2001;7(3):683-694. DOI
- Chipuk JE, Bouchier-Hayes L, Kuwana T, Newmeyer DD, Green DR. PUMA couples the nuclear and cytoplasmic proapoptotic function of p53. Science. 2005;309(5744):1732-1735. DOI
- Cregan SP, Arlt W, Fortin J, et al. Neurodegeneration in PUMA-deficient mice. Cell Death Differ. 2004;11(8):785-795. DOI
- Wan YY, Chi H, Xie M, et al. PUMA regulates neuronal progenitor cell death, survival, and regeneration. Cell Death Differ. 2012;19(8):1279-1289. DOI
- Reimertz C, Kögel D, Rami A, Chittenden T, Prehn JH. Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein PUMA. J Cell Biol. 2003;162(4):587-597. DOI
- U M, Ida H, Nakamura K, et al. PUMA is required for p53-mediated neuronal cell death in response to oxidative stress. J Neurochem. 2007;103(1):196-207. DOI
- Galehdar Z, Sun P, Cregan SW, et al. Neuronal apoptosis in PUMA-deficient mice and its implications for Parkinson's disease. Neurobiol Dis. 2010;38(1):73-81. DOI