Psma4 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Gene Symbol | PSMA4 |
| Full Name | Proteasome Subunit Alpha 4 |
| Chromosomal Location | 15q21.3 |
| NCBI Gene ID | 5685 |
| OMIM | 176844 |
| Ensembl ID | ENSG00000123131 |
| UniProt | P25789 |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Cognitive Decline |
PSMA4 is a gene/protein encoding a key neuronal protein involved in synaptic function, signal transduction, and cellular homeostasis. Dysfunction of PSMA4 is associated with neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and related disorders.
The PSMA4 gene encodes the alpha subunit type 4 of the 20S proteasome. PSMA4 is one of seven alpha subunits that form the outer rings of the 20S proteasome core particle. The proteasome degrades ubiquitin-tagged proteins and is essential for cellular protein homeostasis.
PSMA4 contributes to the structural integrity and catalytic function of the proteasome. It helps maintain neuronal health by degrading damaged proteins, regulatory proteins, and aggregation-prone proteins that accumulate in aging and disease.
PSMA4 and neurodegeneration:
PSMA4 is widely expressed:
The study of Psma4 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.