| Full Name | Prokineticin Receptor 2 |
|---|---|
| Chromosomal Location | 20p12.3 |
| NCBI Gene ID | 128674 |
| OMIM | 607123 |
| Ensembl ID | ENSG00000101292 |
| UniProt | Q8NFJ6 |
| Associated Diseases | Parkinson's Disease, Kallmann Syndrome |
PROKR2 (Prokineticin Receptor 2), also known as GPR73b, is a G protein-coupled receptor that binds prokineticin peptides (PK1/EG-VEGF and PK2). It plays important roles in neurodevelopment, circadian rhythm, and has been implicated in Parkinson's disease[1].
The PROKR2 gene encodes a 384-amino acid G protein-coupled receptor:
PROKR2 is widely expressed in the nervous system:
The study of Prokr2 Gene Prokineticin Receptor 2 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Cheng MY et al. (2006). Prokineticin 2 regulates the survival of dopaminergic neurons. Nat Neurosci ↩︎
Logroscino G et al. (2017). PROKR2 variants and Parkinson's disease risk. Neurology ↩︎
Ng KL et al. (2019). Prokineticin signaling as a therapeutic target in neurodegenerative diseases. Cell Death Dis ↩︎