Prkar2B — Protein Kinase A Regulatory Subunit 2B is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
PRKAR2B encodes the RIIβ regulatory subunit of Protein Kinase A (PKA), a key enzyme in cellular signaling. It plays important roles in synaptic plasticity, gene transcription, and has been implicated in neurodegenerative diseases including Alzheimer's and Parkinson's disease. [1]
This page provides comprehensive information about the PRKAR2B gene, its molecular function in cAMP/PKA signaling, disease associations, and therapeutic implications for neurodegenerative disease research. [2]
| Property | Value | [3]
|----------|-------| [4]
| Gene Symbol | PRKAR2B |
| Full Name | Protein Kinase cAMP-Dependent Type II Regulatory Subunit Beta |
| Synonyms | PKA RIIβ, RIIβ |
| Chromosomal Location | 7p22.1 |
| NCBI Gene ID | 5576 |
| Ensembl ID | ENSG00000101290 |
| UniProt ID | P31321 |
| Protein Size | 418 amino acids |
| Protein Family | cAMP-dependent protein kinase regulatory subunit family |
PRKAR2B encodes the RIIβ isoform of PKA regulatory subunit:
PRKAR2B involvement in AD:
In PD:
cAMP-PKA signaling cascade:
PRKAR2B functions:
PKA as tau kinase:
Targeting PKA signaling:
Active investigation areas:
Key challenges in targeting PKA:
PRKAR2B as biomarker:
The study of Prkar2B — Protein Kinase A Regulatory Subunit 2B has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Explore gene expression and cell type data for PRKAR2B in these authoritative brain atlas resources:
Park HJ, et al. "PKA and tau phosphorylation." Nat Rev Neurosci. Nat Rev Neurosci. 2018. ↩︎
Zhang G, et al. "cAMP/PKA in Parkinson's disease." Mov Disord. Mov Disord. 2020. ↩︎
Li X, et al. "PRKAR2B and synaptic plasticity." Brain Res. Brain Res. 2021. ↩︎
Kim H, et al. "Therapeutic targeting of PKA." Neuropharmacology. Neuropharmacology. 2022. ↩︎