Ppp3Cb Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
PPP3CB (Protein Phosphatase 3 Catalytic Subunit Beta) is a gene (NCBI Gene ID: 5530) located on chromosome 2p22.1 that encodes the catalytic subunit of calcineurin, a calcium-dependent protein phosphatase essential for neuronal signaling, synaptic plasticity, and gene transcription. Calcineurin plays important roles in neurodegeneration and neuroinflammation.
Full Name: Protein Phosphatase 3 Catalytic Subunit Beta
| Property | Value |
|---|---|
| Symbol | PPP3CB |
| Chromosome | 2p21 |
| NCBI Gene ID | 5519 |
| OMIM ID | 114206 |
| Ensembl ID | ENSG00000107738 |
| UniProt ID | P16234 |
Alzheimer's Disease
PPP3CB encodes the catalytic subunit beta of calcineurin, a calcium-dependent phosphatase involved in synaptic plasticity, gene transcription, and neuronal signaling.
Ubiquitous, brain.
The study of Ppp3Cb Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[1] PPP3CB (calcineurin B) in neuronal signaling - Neuroscience, 2017
[2] Calcineurin in synaptic plasticity and memory - Trends in Neurosciences, 2015
[3] PPP3CB and NMDA receptor signaling - Neuropharmacology, 2016
[4] Calcineurin in Alzheimer's disease - Neurobiology of Aging, 2014
[5] PPP3CB in neuroinflammation - Journal of Neuroimmunology, 2018
[6] Calcineurin inhibitors and neuroprotection - Experimental Neurology, 2015
[7] PPP3CB in dendritic spine morphology - Synapse, 2016
[8] Calcineurin and tau pathology - Alzheimer's & Dementia, 2020
RIM proteins and synaptic vesicle priming: Gundelfinger ED, et al. Cell Mol Neurobiol. 2003;23(4):451-465. PMID:14514026
Molecular anatomy of the presynaptic active zone: Südhof TC. Annu Rev Neurosci. 2012;35:439-456. PMID:22462542
Synaptogyrin family in synaptic vesicle cycling: Hubler D, et al. J Mol Neurosci. 2004;23(1-2):33-42. PMID:15126693
PPP3CB (calcineurin B) in neuronal signaling: Yakel JL. Trends Pharmacol Sci. 1997;18(4):124-134. PMID:9143797
RCAN1 in calcineurin signaling and Down syndrome: Ermak G, et al. J Mol Med (Berl). 2009;87(4):353-364. PMID:19139837
NFAT transcription factors in neuronal development and plasticity: Nguyen T, Di Giovanni S. Nat Rev Neurosci. 2008;9(4):283-296. PMID:18334263
CHOP/DDIT3 in ER stress and apoptosis: Oyadomari S, Mori M. Cell Death Differ. 2004;11(4):381-389. PMID:14752508
Synaptic active zone organization: Jackman SL, et al. Neuron. 2016;92(4):651-671. PMID:27984726