Ppp2R2B Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Gene Symbol | PPP2R2B |
|---|---|
| Full Name | Protein Phosphatase 2 Regulatory Subunit B Beta |
| Chromosomal Location | 5q31.3 |
| NCBI Gene ID | [5520](https://www.ncbi.nlm.nih.gov/gene/5520) |
| OMIM | [604326](https://www.omim.org/entry/604326) |
| Ensembl ID | ENSG00000156475 |
| UniProt ID | [Q9Y2T7](https://www.uniprot.org/uniprot/Q9Y2T7) |
| Associated Diseases | Spinocerebellar Ataxia Type 12 (SCA12) |
PPP2R2B encodes the β isoform of the B55 regulatory subunit of protein phosphatase 2A (PP2A). This regulatory subunit targets PP2A to specific substrates, modulating phosphorylation states of key neuronal proteins.
PPP2R2B-containing PP2A complexes:
SCA12 is caused by a CAG repeat expansion in the 5'UTR of PPP2R2B:
Clinical Features:
Disease Mechanism:
PPP2R2B shows regional expression:
Current therapeutic approaches:
The study of Ppp2R2B Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
NeuroWiki - Gene Page | Last Updated: 2026-03-04
PP2A-B55β is a promising target for neurodegenerative disease therapy. Inhibitors that activate PP2A are being developed for AD and PD, while inhibitors are being investigated for certain cancers. The challenge is achieving tissue-specific modulation.
| Approach | Target | Stage | Indication |
|---|---|---|---|
| LB-100 | PP2A activator | Clinical | Solid tumors, AD |
| Small molecule activators | PP2A-B55β | Preclinical | PD |
| PP2A-B55β inhibitors | PP2A-B55β | Discovery | Cancer |
Current research focuses on understanding how PP2A-B55β dysregulation contributes to tau hyperphosphorylation in AD. Studies are investigating the role of PP2A-B55β in α-synuclein phosphorylation in PD. Additionally, research is exploring biomarkers for PP2A activity in cerebrospinal fluid.