Pparg — Peroxisome Proliferator Activated Receptor Gamma is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| PPARG | |
|---|---|
| Gene Symbol | PPARG |
| Full Name | Peroxisome Proliferator-Activated Receptor Gamma |
| Chromosome | 3p25.2 |
| NCBI Gene ID | 5468 |
| OMIM | 601487 |
| Ensembl ID | ENSG00000132170 |
| UniProt ID | P37231 |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Type 2 Diabetes, Lipodystrophy |
This page provides comprehensive information about the PPARG gene and its role in neurodegenerative diseases. The gene encodes a protein involved in various molecular pathways relevant to Alzheimer's disease, Parkinson's disease, and related conditions.
PPARG is a nuclear receptor and transcription factor that regulates:
PPARG forms heterodimers with RXR and binds to PPAR response elements (PPREs) in target genes. It is activated by:
PPARG is expressed in:
The study of Pparg — Peroxisome Proliferator Activated Receptor Gamma has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
This page was created to expand the NeuroWiki gene database for neurodegenerative disease research.