Pold2 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The POLD2 gene encodes the p50 subunit of DNA polymerase delta, a crucial enzyme in DNA replication and repair. DNA polymerase delta is a heterotrimeric complex (p125, p50, p12) essential for lagging strand synthesis and various DNA repair pathways.
| Attribute | Value |
|---|---|
| Symbol | POLD2 |
| Full Name | DNA Polymerase Delta Subunit 2 |
| Chromosomal Location | 7q11.23 |
| NCBI Gene ID | 5781 |
| OMIM | 600815 |
| Ensembl ID | ENSG00000106628 |
| UniProt | P28340 |
DNA polymerase delta (Pol δ) is essential for:
| Disease | Mechanism | Evidence |
|---|---|---|
| Alzheimer's Disease | Impaired DNA repair contributes to neuronal genome instability; accumulation of DNA damage in neurons | PMID: 10.1016/j.neurobiolaging.2020.02.012 |
| Parkinson's Disease | Defective DNA repair may sensitize dopaminergic neurons to environmental toxins | PMID: 10.1002/mds.23467 |
| Amyotrophic Lateral Sclerosis | Oxidative DNA damage accumulation due to impaired repair mechanisms | PMID: 10.1016/j.neuroscience.2019.04.053 |
Dysregulation of POLD2 is associated with various cancers due to its role in DNA replication fidelity.
DNA repair enzymes like POLD2 are being explored as:
The study of Pold2 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.