Pik3C3 — Phosphatidylinositol 3 Kinase Catalytic Subunit Type 3 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3 | |
|---|---|
| Gene Symbol | PIK3C3 |
| Full Name | phosphatidylinositol 3-kinase catalytic subunit type 3 |
| Chromosome | 18q12.3 |
| NCBI Gene ID | 5289 |
| OMIM | 602609 |
| Ensembl ID | ENSG00000055070 |
| UniProt ID | Q9Y2H7 |
| Associated Diseases | Neurodegeneration, Parkinson's Disease, Lysosomal Storage Disorders |
This page provides comprehensive information about the subject's role in neurodegenerative diseases. The subject participates in various molecular pathways and cellular processes relevant to Alzheimer's disease, Parkinson's disease, and related conditions.
PIK3C3 encodes the catalytic subunit of the class III phosphatidylinositol 3-kinase (PI3K-III), which is essential for autophagy and endosomal trafficking. It plays critical roles in:
PIK3C3 is widely expressed:
The study of Pik3C3 — Phosphatidylinositol 3 Kinase Catalytic Subunit Type 3 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.