Per1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
.infobox .infobox-gene
| Gene Symbol | PER1 |
|---|---|
| Gene Name | Period Circadian Regulator 1 |
| Chromosome | 17p13.1 |
| NCBI Gene ID | 5441 |
| OMIM ID | 602260 |
| Ensembl ID | ENSG00000132359 |
| UniProt ID | O15055 |
| Associated Diseases | Neurodegenerative Disorders, Sleep Disorders, Cancer, Metabolic Syndrome |
| --- | --- |
| Categories | Circadian Rhythm, Transcriptional Regulation, Cell Cycle |
PER1 (Period Circadian Regulator 1) is a core circadian clock gene essential for maintaining daily rhythms in mammals. This gene encodes a protein that plays a critical role in the negative feedback loop governing the circadian clock, regulating not only sleep-wake cycles but also numerous physiological processes including hormone secretion, metabolism, and cellular function. Dysregulation of PER1 has been implicated in various neurodegenerative diseases, sleep disorders, and metabolic conditions, making it an important therapeutic target [1][2].
PER1 (Period Circadian Regulator 1) is a core component of the mammalian circadian clock. Together with PER2 and PER3, PER1 forms the negative feedback loop that generates circadian rhythms in gene expression and behavior[1].
The circadian clock operates through a transcription-translation feedback loop:
PER1 has additional roles:
Circadian disturbances are common in AD, and PER1 dysregulation contributes to:
PER1 alterations in PD:
PER1 responds to brain injury:
Timing of treatments based on circadian rhythms:
PER1 dysregulation in cancer:
The study of Per1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[2] Circadian-cell cycle link (2019)
[4] Circadian and neurodegeneration (2022)