Pde9A Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Pde9A Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [1]
PDE9A (Phosphodiesterase 9A) is a cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase that is highly expressed in the brain. It is a therapeutic target for Alzheimer's disease and cognitive enhancement. [2]
| Property | Value |
|---|---|
| Gene Symbol | PDE9A |
| Full Name | Phosphodiesterase 9A |
| Chromosomal Location | 21q22.11 |
| NCBI Gene ID | 5152 |
| OMIM ID | 601926 |
| Ensembl ID | ENSG00000160193 |
| UniProt ID | O76074 |
PDE9A is a ~69 kDa phosphodiesterase:
PDE9A has important neuronal functions:
| Brain Region | Expression Level |
|---|---|
| Hippocampus | Very High |
| Cerebral Cortex | High |
| Cerebellum | Low |
| Basal Ganglia | Moderate |
| Substantia Nigra | Low |
PDE9A is expressed in:
Pde9A Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Pde9A Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.