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| Symbol | PDE2A |
| Full Name | Phosphodiesterase 2A |
| Chromosome | 11q13.4 |
| NCBI Gene | 5139 |
| OMIM | 602952 |
| Ensembl | ENSG00000186642 |
| UniProt | O76074 |
| Associated Diseases | Alzheimer's disease, cardiac function |
PDE2A (Phosphodiesterase 2A) is a cyclic nucleotide phosphodiesterase that hydrolyzes cGMP and/or cAMP. Phosphodiesterases play crucial roles in regulating intracellular signaling pathways, neuronal function, and synaptic plasticity. Dysregulated PDE2A activity has been implicated in neurodegenerative diseases including Alzheimer's disease and Parkinson's disease.
PDE2A hydrolyzes both cAMP and cGMP. It is highly expressed in brain and regulates synaptic plasticity, memory, and emotional behavior.
High expression in hippocampus, cortex, and olfactory bulb.