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| Symbol | PDE11A |
| Full Name | Phosphodiesterase 11A |
| Chromosome | 2q31.1 |
| NCBI Gene | 5173 |
| OMIM | 607429 |
| Ensembl | ENSG00000128605 |
| UniProt | Q9UQ97 |
| Associated Diseases | Cancer, endocrine disorders |
PDE11A (Phosphodiesterase 11A) is a cyclic nucleotide phosphodiesterase that hydrolyzes cGMP and/or cAMP. Phosphodiesterases play crucial roles in regulating intracellular signaling pathways, neuronal function, and synaptic plasticity. Dysregulated PDE11A activity has been implicated in neurodegenerative diseases including Alzheimer's disease and Parkinson's disease.
PDE11A is a dual-specificity phosphodiesterase. Limited expression in brain, mainly in peripheral tissues.
Limited brain expression, higher in testis and adrenal.