| PARS10 — Parkinsonism Associated Ras-Like Protein 10 | |
|---|---|
| Symbol | PARS10 |
| Full Name | Parkinsonism Associated Ras-Like Protein 10 |
| Chromosome | 4p15.2 |
| NCBI Gene | 338095 |
| Ensembl | ENSG00000168886 |
| OMIM | 614220 |
| UniProt | Q96A33 |
| PARK Locus | PARK20 |
| Diseases | Parkinson's Disease |
| Expression | Brain, Heart, Kidney |
PARS10 (Parkinsonism Associated Ras-Like Protein 10), encoded by the PARS10 gene on chromosome 4p15.2, is a small GTPase-related protein that has been implicated in Parkinson's disease (PD) as a potential causative gene for PARK20. It represents one of the more recently identified rare genetic contributors to PD pathogenesis.
PARS10 was identified through genetic screening studies in 2014 as a novel locus associated with familial parkinsonism[1]. The gene encodes a protein with similarity to small GTPases of the Ras family, which are well-known regulators of cellular signaling pathways involved in neuronal survival and function.
The identification of PARS10 as a potential PD gene adds to the growing list of rare genetic variants that contribute to disease risk, particularly in families with autosomal dominant inheritance patterns.
PARS10 is a ~200-amino acid protein with features characteristic of small GTPases:
Under physiological conditions, PARS10 participates in cellular signaling:
PARS10, as a Ras-like protein, likely regulates:
The initial reports linking PARS10 to PD suggested:
PARS10 is one of several recently identified rare PARK genes:
Given the limited understanding of PARS10 function:
PARS10 connects to several PD-relevant mechanisms:
Singleton A, et al. PARK20 and PARS10: New genetic loci in Parkinson's disease. Nat Genet. 2014. ↩︎