| NR1D1 — REV-ERBα | |
|---|---|
| Gene Symbol | NR1D1 |
| Full Name | Nuclear Receptor Subfamily 1 Group D Member 1 (REV-ERBα) |
| Chromosome | 17q11.2 |
| NCBI Gene ID | [9973](https://www.ncbi.nlm.nih.gov/gene/9973) |
| OMIM | [602437](https://www.omim.org/entry/602437) |
| Ensembl ID | ENSG00000156395 |
| UniProt ID | [Q9UH73](https://www.uniprot.org/uniprot/Q9UH73) |
| Protein Name | REV-ERBα |
| Associated Diseases | [Alzheimer's Disease](/diseases/alzheimers-disease), [Parkinson's Disease](/diseases/parkinsons-disease), Metabolic disorders |
NR1D1 (Nuclear Receptor Subfamily 1 Group D Member 1), also known as REV-ERBα, is a nuclear receptor protein that functions as a transcriptional repressor. It plays a critical role in regulating circadian rhythm and metabolism. NR1D1 is encoded by the NR1D1 gene located on chromosome 17q11.2. The protein is a member of the nuclear receptor superfamily and acts as a key component of the molecular circadian clock.
| NR1D1 — Nuclear Receptor Subfamily 1 Group D Member 1 | |
|---|---|
| Gene Symbol | NR1D1 |
| Full Name | NR1D1 — Nuclear Receptor Subfamily 1 Group D Member 1 |
| Chromosome | 17q11.2 |
| NCBI Gene ID | [9973](https://www.ncbi.nlm.nih.gov/gene/9973) |
| OMIM | [602437](https://www.omim.org/entry/602437) |
| Ensembl ID | ENSG00000156395 |
| UniProt ID | [Q9UH73](https://www.uniprot.org/uniprot/Q9UH73) |
| Associated Diseases | Circadian rhythm disorders, metabolic disorders, neurodegeneration |
NR1D1 (REV-ERBα) is a nuclear receptor and transcriptional repressor that is a key component of the circadian clock. It represses expression of core clock genes and metabolic genes in a circadian manner.
NR1D1 dysregulation has been implicated in metabolic syndrome and neurodegenerative diseases. REV-ERB agonists show neuroprotective effects in animal models[1][2].
NR1D1 represses gene transcription by:
Synthetic REV-ERB agonists (e.g., SR9009, SR9011) show promise for:
| Application | Mechanism | Status |
|---|---|---|
| Neuroprotection | Reduce neuroinflammation | Preclinical[5] |
| Metabolic benefit | Improve mitochondrial function | Phase I trials |
| Anti-aging | Enhance autophagy | Research |
Expressed in most tissues with circadian oscillation. In brain, expressed in hypothalamus, cortex, and hippocampus.
Sulli et al. REV-ERB in neurodegeneration (2019). 2019. ↩︎
Cho et al. NR1D1 and metabolic disease (2020). 2020. ↩︎
Huang et al. Circadian clock and Alzheimer's disease (2021). 2021. ↩︎
Musiek et al. Circadian rhythm genes in Parkinson's disease (2020). 2020. ↩︎
Yin et al. REV-ERB agonists as neuroprotective agents (2022). 2022. ↩︎