NR1D1 (Nuclear Receptor Subfamily 1 Group D Member 1), also known as REV-ERBα, is a nuclear receptor protein that functions as a transcriptional repressor. It plays a critical role in regulating circadian rhythm and metabolism. NR1D1 is encoded by the NR1D1 gene located on chromosome 17q11.2. The protein is a member of the nuclear receptor superfamily and acts as a key component of the molecular circadian clock.
| NR1D1 — Nuclear Receptor Subfamily 1 Group D Member 1 | |
|---|---|
| Gene Symbol | NR1D1 |
| Full Name | NR1D1 — Nuclear Receptor Subfamily 1 Group D Member 1 |
| Chromosome | 17q11.2 |
| NCBI Gene ID | 9973 |
| OMIM | 602437 |
| Ensembl ID | ENSG00000156395 |
| UniProt ID | Q9UH73 |
| Associated Diseases | Circadian rhythm disorders, metabolic disorders, neurodegeneration |
NR1D1 (REV-ERBα) is a nuclear receptor and transcriptional repressor that is a key component of the circadian clock. It represses expression of core clock genes and metabolic genes in a circadian manner.
NR1D1 dysregulation has been implicated in metabolic syndrome and neurodegenerative diseases. REV-ERB agonists show neuroprotective effects in animal models.
Expressed in most tissues with circadian oscillation. In brain, expressed in hypothalamus, cortex, and hippocampus.
NR1D1/REV-ERBα has been extensively studied for its role in circadian rhythm regulation. Research has shown that it acts as a core component of the circadian clock, regulating the expression of clock genes and metabolic genes in a tissue-specific manner. Recent studies have expanded our understanding of NR1D1's role in neurodegeneration, particularly in Alzheimer's disease and Parkinson's disease.