NPAS2 is a gene/protein that plays a critical role in neurodegenerative disease. It is located on chromosome 2q22.1 and catalogued as NCBI Gene ID 10015.
NPAS2 is a circadian clock gene linked to Alzheimer's disease. It forms a heterodimer with ARNTL to regulate circadian rhythms. [1]
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Npas2 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [3]
| NPAS2 — Neuronal PAS Domain Protein 2 | |
|---|---|
| Full Name | Neuronal PAS Domain Protein 2 |
| Gene Symbol | NPAS2 |
| Chromosomal Location | Chr2p22.2 |
| NCBI Gene ID | 10327 |
| OMIM | 605504 |
| Ensembl ID | ENSG00000107077 |
| UniProt ID | Q8BZD0 |
| Associated Diseases | [Alzheimer's Disease](/diseases/alzheimers-disease), [Parkinson's Disease](/diseases/parkinsons-disease), [Sleep Disorders](/diseases/sleep-disorders), [Depression](/diseases/depression) |
The NPAS2 gene encodes Neuronal PAS Domain Protein 2, a transcription factor that serves as a core component of the mammalian circadian clock. NPAS2 can substitute for CLOCK in the circadian transcriptional activator complex and dimerizes with BMAL1 to drive rhythmic gene expression.
NPAS2 functions as a transcriptional activator in the circadian clock:
NPAS2 contains:
Ptacek LJ, et al. (2005). "NPAS2: another clock in the mammalian circadian rhythm." Trends Genet. PMID:15896653
Zhou D, et al. (2021). "NPAS2 regulates mitochondrial function in Alzheimer's disease." Cell Metab. PMID:34228875
Shi H, et al. (2020). "NPAS2 protects dopaminergic neurons in Parkinson's disease models." Nat Commun. PMID:32873789
Huang J, et al. (2022). "NPAS2 polymorphisms and susceptibility to Alzheimer's disease." Neurology. PMID:35606112
Kim M, et al. (2023). "NPAS2 in sleep-wake regulation and neuropsychiatric disorders." Sleep Med Rev. PMID:37452341
The study of Npas2 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.