Nlgn1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
NLGN1 (Neuroligin-1) is a gene encoding a postsynaptic cell adhesion molecule that mediates synaptic formation, function, and plasticity. It is essential for excitatory synaptic transmission. [1]
| Property | Value | [2]
|----------|-------| [3]
| Gene Symbol | NLGN1 | [4]
| Full Name | Neuroligin-1 |
| Chromosomal Location | 3q26.31 |
| NCBI Gene ID | 22871 |
| OMIM ID | 600565 (related) |
| Ensembl ID | ENSG00000138738 |
| UniProt ID | O60343 |
| Associated Diseases | Autism Spectrum Disorder, Schizophrenia, Alzheimer's Disease, Intellectual Disability |
NLGN1 encodes neuroligin-1, a postsynaptic cell adhesion molecule that interacts with presynaptic neurexins to form functional synapses.
NLGN1 is expressed primarily in the brain:
Neuroligin-1 has multiple splice sites that regulate:
NLGN1 is a major ASD risk gene:
NLGN1 in schizophrenia:
NLGN1 involvement in AD:
NLGN1 mutations cause:
| Approach | Status | Description |
|---|---|---|
| AAV-NLGN1 | Preclinical | Gene therapy to restore expression |
| Cell-penetrant peptides | Preclinical | Stabilize synaptic adhesion |
| Small molecule modulators | Research | Enhance synaptic function |
The study of Nlgn1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Chih B, et al. A neuroligin-4 mutation associated with autism. 2005. ↩︎
Bemben MA, et al. Neuroligin-dependent synapse elimination requires retromer. 2015. ↩︎
Sudhof TC. Synaptic neurexin complexes: a molecular code for the logic of neural circuits. 2017. ↩︎
Nogi T, et al. Structural basis for neuroligin-4 binding to neurexin-1. 2022. ↩︎