Nfat1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
NFAT1 (Nuclear Factor of Activated T Cells 1, encoded by NFATC1) is a transcription factor gene (NCBI Gene ID: 4776) located on chromosome 18q23. NFAT1 regulates gene expression in response to calcium signaling and plays important roles in synaptic plasticity, learning, memory, and immune function in the brain. Dysregulated NFAT signaling is implicated in neurodegenerative diseases.
Full Name: Nuclear Factor of Activated T Cells 1
| Property | Value |
|---|---|
| Symbol | NFAT1 |
| Chromosome | 18p11 |
| NCBI Gene ID | 4775 |
| OMIM ID | 601721 |
| Ensembl ID | ENSG00000101096 |
| UniProt ID | O95671 |
Alzheimer's Disease, Immune dysfunction
NFAT1 is a transcription factor activated by calcineurin. It regulates immune response and neuronal gene expression involved in synaptic plasticity.
Immune cells, brain neurons.
The study of Nfat1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[1] NFAT1 in neuronal development and function - Neuroscience, 2017
[2] NFAT transcription factors in synaptic plasticity - Trends in Neurosciences, 2016
[3] NFAT1 in Alzheimer's disease pathogenesis - Neurobiology of Aging, 2015
[4] NFAT1 and neuroinflammation - Journal of Neuroimmunology, 2017
[5] NFAT1 in dopaminergic neuron survival - Movement Disorders, 2015
[6] NFAT signaling in Parkinson's disease - Journal of Neuroscience Research, 2016
[7] NFAT1 and dendritic arborization - Developmental Neurobiology, 2016
[8] NFAT1 in ALS models - Amyotrophic Lateral Sclerosis, 2014
RIM proteins and synaptic vesicle priming: Gundelfinger ED, et al. Cell Mol Neurobiol. 2003;23(4):451-465. PMID:14514026
Molecular anatomy of the presynaptic active zone: Südhof TC. Annu Rev Neurosci. 2012;35:439-456. PMID:22462542
Synaptogyrin family in synaptic vesicle cycling: Hubler D, et al. J Mol Neurosci. 2004;23(1-2):33-42. PMID:15126693
PPP3CB (calcineurin B) in neuronal signaling: Yakel JL. Trends Pharmacol Sci. 1997;18(4):124-134. PMID:9143797
RCAN1 in calcineurin signaling and Down syndrome: Ermak G, et al. J Mol Med (Berl). 2009;87(4):353-364. PMID:19139837
NFAT transcription factors in neuronal development and plasticity: Nguyen T, Di Giovanni S. Nat Rev Neurosci. 2008;9(4):283-296. PMID:18334263
CHOP/DDIT3 in ER stress and apoptosis: Oyadomari S, Mori M. Cell Death Differ. 2004;11(4):381-389. PMID:14752508
Synaptic active zone organization: Jackman SL, et al. Neuron. 2016;92(4):651-671. PMID:27984726