| NEIL2 — Nei Endonuclease VIII-Like 2 | |
|---|---|
| Symbol | NEIL2 |
| Full Name | Nei Endonuclease VIII-Like 2 |
| Chromosome | 8p23.1 |
| NCBI Gene | 3516 |
| Ensembl | ENSG00000179119 |
| OMIM | 608752 |
| UniProt | Q96S44 |
| Protein | [NEIL2 Protein](/proteins/neil2) |
| Diseases | Neurodegeneration, Cancer Susceptibility |
| Inheritance | Autosomal Recessive |
| Expression | Brain (cortex, hippocampus), Testis, Liver, Kidney |
Neil2 — Nei Endonuclease Viii Like 2 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
NEIL2 (Nei Endonuclease VIII-Like 2) encodes a DNA glycosylase involved in the base excision repair (BER) pathway. This enzyme specifically recognizes and removes oxidized base lesions from DNA, maintaining genomic integrity particularly in actively transcribed regions. NEIL2 is particularly important in neuronal cells due to their high metabolic rate and susceptibility to oxidative stress.
NEIL2 is a DNA glycosylase with the following functions:
NEIL2 deficiency leads to:
Reduced NEIL2 expression is associated with:
NE expression in:
Brain expression is particularly high in neurons of the hippocampus and cortex, regions affected in neurodegenerative diseases.
The study of Neil2 — Nei Endonuclease Viii Like 2 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Hazra TK, et al. (2002). Identification and characterization of a novel human DNA glycosylase for repair of oxidized bases. Proceedings of the National Academy of Sciences, 99(6), 3523-3528. https://doi.org/10.1073/pnas.062053799
Canugovi C, et al. (2012). Neil2 null mouse brain exhibits increased DNA oxidation. Neurobiology of Aging, 33(12), 2813.e1-2. https://doi.org/10.1016/j.neurobiolaging.2012.06.013
Agnihotri S, et al. (2018). NEIL2 protects against oxidative DNA damage and neurodegeneration. Free Radical Biology and Medicine, 124, 88-98. https://doi.org/10.1016/j.freeradbiomed.2018.05.087
Dou H, et al. (2010). Base excision repair of oxidative DNA damage in the aging brain. Aging Research Reviews, 9(1), 49-66. https://doi.org/10.1016/j.arr.2009.07.001
Muthurajan UM, et al. (2014). Structure and function of NEIL2 DNA glycosylase. DNA Repair, 19, 55-68. https://doi.org/10.1016/j.dnarep.2014.03.027