Ndufaf3 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Ndufaf3 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| NADH Dehydrogenase Complex Assembly Factor 3 | |
|---|---|
| Gene Symbol | NDUFAF3 |
| Full Name | NADH Dehydrogenase Complex Assembly Factor 3 |
| Chromosome | 3p21.31 |
| NCBI Gene ID | 55244 |
| OMIM | 618196 |
| Ensembl ID | ENSG00000163293 |
| UniProt ID | Q9P0U4 |
| Associated Diseases | Leigh Syndrome, Mitochondrial Complex I Deficiency |
NDUFAF3 encodes a mitochondrial complex I assembly factor. Together with NDUFAF4, this protein forms a subcomplex essential for the assembly of the complex I core. NDUFAF3 is crucial for the early stages of complex I biogenesis.
Expressed in tissues with high mitochondrial energy demands.
| Disease | Role | Mechanism |
|---|---|---|
| Leigh Syndrome | Causative | Complex I assembly defect |
Ndufaf3 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Ndufaf3 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.