Ncstn Gene Nicastrin is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
--- [1]
title: NCSTN Gene [2]
description: Nicastrin - component of the gamma-secretase complex [3]
| NCSTN Gene | |
|---|---|
| Symbol | NCSTN |
| Full Name | Nicastrin |
| Chromosomal Location | 1p31.3 |
| NCBI Gene ID | 46635 |
| OMIM | 605227 |
| Ensembl ID | ENSG00000162736 |
| UniProt ID | Q9P0R3 |
| Associated Diseases | Alzheimer's Disease, Hidradenitis Suppurativa |
Nicastrin (NCSTN) is an essential component of the gamma-secretase complex, a multiprotein aspartyl protease that catalyzes the intramembranous cleavage of various type I transmembrane proteins. Nicastrin acts as a cofactor for presenilin and is critical for the proteolytic activity of gamma-secretase.
Nicastrin is a single-pass transmembrane glycoprotein that functions as a key structural and regulatory component of the gamma-secretase complex.
In the brain, NCSTN is expressed in:
High expression is observed in the hippocampus, cerebral cortex, and basal ganglia - regions affected in Alzheimer's disease.
NCSTN is a central component of the amyloidogenic processing pathway:
NCSTN mutations have been associated with hidradenitis suppurativa (HS), a chronic inflammatory skin disease:
The study of Ncstn Gene Nicastrin has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
The Allen Brain Atlas provides comprehensive gene expression data across brain regions and cell types.
Search for expression data on the Allen Brain Atlas:
Luu L, et al. (2020). Nicastrin in Alzheimer's disease. Luu L, et al. 2020. ↩︎
Dries DR, et al. (2009). Nicastrin function in gamma-secretase. Dries DR, et al. 2009. ↩︎
Cheng H, et al. (2013). NCSTN mutations and familial acne inversa. Cheng H, et al. 2013. ↩︎